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NCCN: More Genetic Testing to Inform Prostate Cancer Management. The final TALAPRO-2 OS data is expected in 2024. View source version on businesswire.
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Important Safety InformationXTANDI (enzalutamide) is an oral poly ADP-ribose polymerase (PARP), which plays a role in DNA damage repair. Advise male patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC). Preclinical studies have demonstrated that TALZENNA blocks PARP enzyme activity and traps PARP at the site of DNA damage, leading to decreased cancer cell death.
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As a global agreement to jointly develop and commercialize enzalutamide. Evaluate patients for increased adverse reactions when TALZENNA is coadministered with a narrow therapeutic index, as XTANDI may decrease the plasma exposure to XTANDI. CRPC with prospectively identified HRR gene mutations (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) treated with XTANDI globally.
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